Replication Strategy of ss(+)RNA Viruses
translation of genomic RNA viral replicase makes (-)RNA viral replicase makes (+)RNA and mRNA viral replicase makes (+)RNA and mRNA mRNA translated - structural proteins CP biases production of (+)RNA? Assembly occurs

Note: look at status bar when mouse is over numbers in picture for explanations of steps

Note: this is an animated GIF, which takes about 30 sec to cycle through completely.

Note:

 

Steps in Replication

1. Translation of virion RNA as mRNA (early products=RDRP)

2. Synthesis of (-)sense RNA on (+)sense template by RDRP (=formation of replicative complex, RC)

3. Synthesis of (+)sense RNA, mRNA and (-)sense RNA

4. Translation of (+)sense and mRNA, synthesis of structural protein (which biases RC to produce (+)sense RNA?)

5. Assembly of structural protein and (+)sense RNA and maturation of virions

Return to RNA Genomes

copyright Ed Rybicki, 1995, August 1998