Replication Strategy of dsRNA Viruses

This is an animated GIF file.  It takes about 15 sec to cycle all the way through.

Steps in Replication

1. Primary transcription in virion core in cytoplasm by viral RDRP, and export of (+)sense RNA to cytoplasm

2. Translation of (+)sense RNA, accumulation of viral proteins

3. Assembly of (+)sense RNA and viral proteins into immature virions

4. Transcription of (+)sense RNA into dsRNA in virions by viral RDRP

5. Secondary transcription of dsRNA

6. Final assembly / maturation of virions

Return to RNA Genomes

copyright Ed Rybicki, 1995 and August 1998