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My main research interests are presently in making human and animal vaccine candidates in plants and insect cells: these include vaccines for mucosal Human papillomaviruses (HPV) and Human immunodeficiency virus type 1 (HIV-1) subtype C. We also work on characterisation and molecular biology of the parrot Beak and feather disease virus and the possibility of making vaccines and therapeutics for the virus disease. I still have an interest in the diversity of southern African Mastreviruses (family Geminiviridae), the molecular determinants of pathogenicity and host range in these viruses, and especially in Maize streak virus, the use of geminiviruses as vectors of foreign genes in plants, and in the engineering of viral resistance, especially in maize.

Blue-Tongue virusBeak and feather disease Plant produced Rotavirus virus-like particle
Plant produced BTV8 virus-like particle
Virus graphics courtesy of Russell Kightley